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KMID : 0043320110340050727
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Archives of Pharmacal Research
2011 Volume.34 No. 5 p.727 ~ p.731
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The conformation and CETP inhibitory activity of [10]-dehydrogingerdione isolated from Zingiber officinale
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Choi Soon-Yong
Park Gil-Soon
Lee Sung-Yoon
Kim Ji-Yeon
Kim Young-Kook
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Abstract
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In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its 1HNMR, 13C-NMR, and 1H-1H COSY, HMBC, HMQC and NOESY, more precise structure, compared with its originally proposed structures, of [10]-dehydrogingerdione has been elucidated. This active compound inhibited human plasma CETP with IC50 values of 35 μM.
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KEYWORD
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Cholesteryl ester transfer protein, Gingiber officinale, Inhibitor
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